Is the microbiome just a trend, or here to stay? According to Wayne Finlayson of Servatus Biopharmaceuticals, the unique constellation of microbial genetic material inside us all will revolutionize and redefine the way we treat disease. Watch as he and Director of In Vivo Pharmacology, Dr. Rana Samadfam, discuss the role of the microbiome in disease and therapeutic development.
The partnership with Charles River started two years ago when we were wanting to do some various animal models in inflammation, in both arthritis and ulcerative colitis and a few other things. The partnership has given us more than just animal models, it has given us advice in the area of regulatory affairs and general discovery of work to develop our drugs and develop our microbial bio therapeutics, especially in the new era in the microbiome space, and they help us interpret the data as well so it's been a great partnership and we can rely on Charles River's data.
Microbiome right now is a hot topic. It is relevant to arthritis, it's relevant to IDD, Parkinson, Alzheimers, and list goes on and on. My question is that what you feel about microbiome, is it here to stay?
Yeah. You're exactly right, it's very much a hot topic so I think it is here to stay and I think it will revolutionize or redefine the way we treat diseases like inflammatory bowel disease and arthritis and so forth.
What are challenges in microbiome area? Why we are having so much difficulty in reproducing some of the data?
I think microbiome is extremely complex. There are a lot of things we don't know and how those bacteria in our human system affects various diseases and people in general and each person is probably very different and so will have a slightly different effect. I think the challenge is actually identifying which of the bacteria that can be useful in developing therapies and which won't be. How do you think germ free animals will redefine microbiome research?
I think because the microbiome is so complex, as scientists, we tend to want to break it down to try and find and define the parameters and germ free mice actually do that for us. I think that's a starting step to understanding a very complex system.