Learn more about our neuroscience portfolio by watching our webinar series.

On-Demand Webinars

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Webinar Series: Nervous System Pain - From DRGs to In Vivo Pharmacology Studies

This webinar series looks at an ex vivo example to an in vivo model that uses imaging technology to diagnose and treat mono and poly-neuropathic pain. It also covers the mechanistic aspects of acute, inflammatory and joint pain models that might help in the discovery of novel analgesics.

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CNS Three Part Series: Translation from Rodents to Larger Animals

Learn how using larger animals for in vivo pharmacology studies improves accuracy in mimicking the human phenotype from PK/PD profiling, neuroimaging, and gene therapy studies.

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Person watching Translating Neurological Stem Cell Research into Therapies for Today’s Patients webinar.

Translating Neurological Stem Cell Research into Therapies for Today’s Patients

Neurological impairments are usually irreversible as a result of limited regeneration in the central nervous system. The regenerative capacity of stem cells makes them an attractive candidate for transplantation therapies, with many stem cells showing promise in basic research and preclinical trials. Learn about the cellular and molecular characteristics of embryonic stem cells, induced pluripotent stem cells, neural stem cells, and their in vitro and in vivo derivatives that could lay the foundation of future CNS regenerative therapies.

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CNS Neurons in CNS disease models

CNS Assessments from Ex Vivo to In Vitro

Adverse central nervous system (CNS) effects have played a large role in determining the failure of many drug candidates within preclinical safety assessments. To help address this, Charles River has developed an array of in vitro electrophysiological assays to evaluate CNS disease models. See how our scientists are paving the way to promote accurate evaluation and identify potential risks earlier in development.

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A graphical image of a neuron encased in myelin sheath relevant to the main Multiple Sclerosis phenotype

Tackling Neuroimmunity of Multiple Sclerosis

Tune in to hear how scientists are using neuroinflammation in vitro assays like NanoString gene expression panels to analyze an in vivo pharmacologically-induced form of multiple sclerosis.

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A graphical image of many neurons with long axons in pink, purple and yellow hues

A Molecular Journey to Investigate Memory Enhancement

Follow the discovery and optimization of a novel GABAA α5-selective negative allosteric modulator (NAM) which showed improved hippocampal memory function.

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image of migration scratch assay

The Power of High Content Imaging in Drug Discovery

Imagine the ability to visualize and measure phenotypic changes at the subcellular level in disease-relevant cell-based assays, all in real time, and at the earliest stages of drug discovery. That’s the power of high content imaging (HCI) using multi-parametric techniques, a vital tool that can guide your discovery program to success.

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A graphical image of a DNA helix with a purple discolored portion to indicate a genetic mutation relevant to rare disease.

A Translational Approach to Monitoring Batten Disease

Learn how noninvasive preclinical neuroimaging, locomotor activity, and behavioral testing in animal models can effectively track the phenotypic changes of disease progression that also appear in human patients.

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Immunostaining of iPSC derived neurons with BIII Tubulin and DAPI

Human iPSC-derived Cells for CNS Drug Discovery

Learn how advanced cellular reprogramming technology can enhance your translational CNS research with phenotypic screening that uses disease-relevant neural cells.

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An image of a human brain inside a human head with the mid-brain section highlighted.

Enhancing CNS Target Validation with Large Animal Translation

Finding drugs that cross the blood-brain barrier remains one of the greatest challenges for CNS drug seekers. Learn how translational large animal models help scientists develop effective brain-penetrant drugs.

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