When testing a novel compound in vivo, rapid elimination can result in mistaken assessment of activity. Rats and mice generally eliminate test compounds more rapidly than humans. After a single injection, plasma concentration rises to a peak and then declines rapidly until the compound is eliminated. Such extreme variability in exposure can influence the expression of drug action, meaning the data from such experiments can be misleading.
This webinar discusses:
- The therapeutic index of a drug, including those of proteins, peptides, and other rapidly eliminated compounds
- Comparative research examples where constant dosing levels of test compounds from infusion techniques allowed drugs to fully develop their biological effects
- Reducing animal stress caused by repeated handling and injections
- Cost implications of drug administration methods
- José R. Gadea, BS, Senior Product Manager, DURECT Corporation