Targeted protein degradation, an alternative approach to conventional inhibitors, involves hijacking the cells’ own protein disposal process to degrade disease-causing proteins. We can loosely call this a “Chemical CRISPR” approach. Aiming to control protein abundance, not function, it offers the advantages of accessibility to difficult targets, catalytic activity, and the potential to achieve tissue or cell population selectivity.
In this webinar, biology and chemistry leads for the CHDI HDAC4 inhibitor project will share how they successfully handled multiple difficult and atypical targets with a “chemical CRISPR” protein degradation approach.
Will Esmieu, PhD
Vad Lazari, PhD
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