In this webinar, we consider the challenges of conventional recordings of electrophysiological parameters in acute brain slices and will demonstrate how they can be tackled by the use of multielectrode array (MEA) technology. Using examples of evoked and spontaneous activity in hippocampal and cerebellar slices, scientists from Discovery from Charles River will discuss how these approaches can be used for characterization of genetically altered animals and neuropharmacological studies.
This webinar is useful for neuroscientists who recognize electrophysiological experiments in slices as an important step in validating the effects of drugs on the central nervous system (e.g., after radioligand binding assays, when target engagement needs to be confirmed by functional studies in situ, prior to more costly experiments in live animals). In addition, since changes in synaptic transmission or modified patterns of spontaneous firing can give information about cellular and network mechanisms of numerous pathological states modeled in animals, this webinar should be interesting to scientists that study Alzheimer’s disease, Huntington’s disease and other CNS disorders.
- Maksym Kopanitsa, PhD, Head of Electrophysiology
- Antti Nurmi, PhD, Director of Science