We’ve all heard about the low endotoxin recovery (LER) phenomenon. But what exactly is LER and, more importantly, what do we know about its potential effects on patient safety and the validity of the LAL test?

This webinar addresses that question, with a focus on:

  • The similarities and differences between bacterial endotoxins and the RSE/CSE calibration standards
  • LER and “masking”
  • LER and patient safety
  • LER and the United States Pharmacopeia (USP) <85> test method validity
  • The rationale behind the USP’s proposed new endotoxin preparation


  • Karen Zink McCullough, BA, MS, Owner and Principal Consultant, MMI Associates