Many researchers would agree that the extreme complexity of biological systems we study are a key factor impacting research reproducibility. For studies employing transgenic rodent lines, a lack of understanding of genetic backgrounds, as well as genetic drift, genetic contamination, and genotyping inconsistencies, all contribute to the issue of reproducibility in mouse studies.
We cover the following topics in this presentation:
- Key factors impacting genetic background and characterization
- Common inconsistencies/errors in genotyping and employing the latest tools/technology
- Best practices for establishing rapid and reliable testing protocols
A companion Q&A page gives additional information in great detail.
Jean Cozzi, PhD
Sylvie Jacquot, PhD
Head of Genotyping Service
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