Webinar Series: Transgenic Mouse and Rat Model Creation

Effective research depends on finding the most relevant model for the application. Our expert staff work with clients from concept to model creation using the latest CRISPR/Cas9 and RNAi technology to deliver the research animals they require for their studies. How can we help you? Request a quote or email us.

Learn more about this innovative technology by watching our webinar series.

CRISPR/Cas9: The Good, The Bad and The Ugly


This webinar presents how we've generated most of the desired structural variant and CNV rearrangements - achieving deletions, duplications, and inversions of genomic regions as large as 24.4 Mb in rodents (the good). However, we must also consider limitations of modifying “big” genomic sequences (the bad) and how precise validation of the lines generated by CRISPR/Cas9 is demanded (the ugly).

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Modelling Human Disease in Rodents with CRISPR/Cas9 Genome Editing


This webinar discusses the promise CRISPR/Cas9 has for rodent studies along with strategies for developing accurate and predictive models to better understand and treat human disease.

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RNAi and CRISPR/Cas9: Revolutionizing Drug Discovery


This webinar discusses how Charles River’s model creation partner, Mirimus, has leveraged RNA interference (RNAi) and CRISPR/Cas9 technologies to enhance the speed and precision of new genetically engineered mouse models.

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The Cre-Toolbox: Revealing Gene Functions with Cre-lox Recombination


After a brief introduction of the Cre-lox technology, this webinar discusses:

  • Using Cre-lox to understand pleiotropy and dissecting gene functions
  • Overcoming embryonic and early postnatal lethality
  • Inducible inactivation with the creERT2 system
  • Phenotypes induced by Cre driver, Tamoxifen toxicity, Cre leakiness: What are the unexpected complexities and technical limitations?
  • CRISPR/Cas9 genome editing for in vivo spatial and/or temporal gene inactivation

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