Immunology Research & Drug Development
Take a 3D Tour of One of Our Immunology & Infection Laboratories
Allow our experts to take you on a 360-degree immersive tour, where you can explore our innovative equipment and how it works to result in a better understanding of the immune system.
From Discovery To Safety: Smooth Out the Kinks
Primary cell assays can provide early information on efficacy, mechanism of action (MoA), and target engagement. In vitro studies reduce costs by shifting attrition to early phases, demonstrating the ability to translate into the clinic and de-risking the progression into expensive in vivo models. You can then move your drug to the next step by selecting your animal model and we can also provide pharmacology testing thanks to our disease and PD models.
Predictive immunotoxicology and immunology endpoints will help you to bring your IND program to FIH trial. At the clinical stage, our biomarkers services and biologics testing solutions will provide all the support and expertise needed.
Webinar: In Vivo Dermal Models for Drug Screening
This webinar presents various in vivo dermal models that mimic atopic dermatitis clinical conditions.
Cell & Gene Therapy
Video Series: Planning for a Successful CAR-T IND During Early Discovery: Presentations
Thanks to this video series, learn how to avoid common pitfalls and how our expertise can help guide your program to success.
Webinar: Tackling Neuro-Immunity in Multiple Sclerosis
This webinar examines the intricacies of EAE and decode the mechanisms before and after certain treatments, from gene expression profiling to advanced neuroimaging and behavioral testing.
Choose the Right Model for Your Immunology Research Development
We provide animal models and services to further your immunology and inflammatory disease research. If your research requires the use of specialized or genetically modified models, our experts will work with you to customize and create them for your study using the latest model creation technologies.
Basic Research Products & Services
Start With In Vitro Testing
To navigate immune system complexity, our team of expert immunologists offer in vitro immunology assays, using primary human and rodent cells, to perform immunological and pharmacological investigations that will help you fully understand your drug.
Pharmacology Testing Impact
In a translational approach to discovery and development, we combine our inflammation and autoimmune models with relevant biomarkers such as flow cytometry and histologic analysis, for a study design tailored to meet your immunology research program milestones.
Let our experts help you perform your immunology testing. We will partner with you to develop the best translational path for your therapeutic, provide detailed regulatory expectations, and offer technical expertise in required assay formats. By using this comprehensive approach, you’ll have the most rapid and cost-effective program possible, from proof of concept, to safety assessment, and finally to clinic.
The ICH S8 guideline for human pharmaceuticals with immunomodulatory actions recommends a weight-of-evidence approach to assess potential immunotoxicity risk. Additional immunotoxicity endpoints reflecting the mechanism of action of the compound should be included within study designs.
Webinar: Assessing the Safety and Immunotoxicity of Monoclonal Antibodies
How to address the safety concerns of mAbs by immunogenicity testing, through ADA assay to nAb assay?
Webinar: Utilizing TDAR Assay to Assess Immune Checkpoint Inhibitors
Discover recent advances in the TDAR assay to evaluate immuno-stimulation in non-human primates. Find out how this model can benefit your drug development program.
Serving the needs of both small and large molecule developers for immunology research, we offer a broad range of standard and specialized laboratory services to complement and enhance drug development programs, from discovery through safety and clinical trials.
We provide a comprehensive range of testing programs and equipment to support pharmaceutical development. Our biologics testing solutions and portfolio of microbial quality control systems and services help clients ensure the safety, quality, and compliance of their products. We support large molecule manufacturing from early preclinical formulation development through clinical and commercial manufacturing and release.
Exceptional support of the entire drug discovery and development process is a Charles River hallmark. As a customer-focused organization committed to advancing science and helping clients reach their goals, we continually strive to develop solutions that extend our support of their efforts.