Immunology

The immune system protects us from infectious disease through various lines of defense, however when the immune response is abnormal it can result in disease. There are few treatments for most disorders of the immune system. The exciting and broad area of immunology intersects multiple therapeutic areas; inflammation and autoimmune disease, as well as areas not traditionally considered immunogenic, including neurodegeneration, rare diseases, and even the progression of cancer.

The immune system is a complex environment; are you aware of all the diverse immunological mechanisms that could impact the results of your drug development studies?

immunology, Dendritic cell, antigen-presenting immune cell

The study of the different components of the immune system is critical for discovery and development of safe and effective therapeutics. Charles River offers both the knowledge and experience in the advancement and direction of immunology research from early discovery, through in vivo pharmacology, safety assessment, and into clinical studies.

Charles River provides animal models and services to further your immunology and inflammatory disease research. And, if your research requires the use of specialized or genetically modified models, our experts will work with you to customize and create them for your study using the latest model creation technologies.

Basic Research Products & Services

There is increasing recognition that the field of immunology intersects with and will open new treatment avenues in many different therapeutic areas. Drug discovery in these new treatment areas requires an expert understanding of not only the extensive pathways involved in the immune response, but also the complex mechanisms that activate and regulate those pathways.

Charles River has over 200 in-house immunologists who understand these processes, and routinely run specialist in vivo models and primary cell assays that closely mimic human biology and are suitable for immunology drug discovery.

Charles River’s expertise in both immunology and other key therapeutic areas such as neurology and oncology make us uniquely suited to support client’s programs.

Discovery Immunology Services


Other Discovery Immunology Models


Immunology Resources

From complete IND-enabling programs to stand-alone assessments, our Safety Assessment team provides a full range of in vivo and in vitro testing services. Our Scientific Advisory Services team adds support and value to your project with their expertise and leadership. Working as a cross-functional group, the team collaborates with you to provide advice from medical, operational, regulatory and cost-efficiency perspectives. The relationships they foster with industry leaders and key professionals allow them to provide deeper insights and strategic guidance for your program.

Safety Assessment Services

With decades of experience in the field, we can advise on selecting the appropriate analytical methodology, biomarkers, pathology services, and toxicological endpoints to best evaluate an immune response.

Laboratory Support Services

We offer full-service support across the entire drug discovery and development continuum, including products and services not specific to therapeutic area or indication.

Serving the needs of both small and large molecule developers, we offer a broad range of standard and specialized laboratory services to complement and enhance drug development programs, from discovery through safety and clinical trials.

We provide a comprehensive range of testing programs and equipment to support pharmaceutical development. Our biologics testing solutions and portfolio of microbial quality control systems and services help clients ensure the safety, quality and compliance of their products. We support large molecule manufacturing from early preclinical formulation development through clinical and commercial manufacturing and release.

Exceptional support of the entire drug discovery and development process is a Charles River hallmark. As a customer-focused organization committed to advancing science and helping clients reach their goals, we continually strive to develop solutions that extend our support of their efforts.

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