Musculoskeletal Disease

Charles River offers services in the area of musculoskeletal research that combine established discovery and preclinical program development expertise with a host of novel bone research technologies to provide highly specialized evaluations of bone disease and bone quality. Our musculoskeletal research scientists can assess the effect of a drug in vivo or ex vivo on bone at toxicological and pharmacological doses and facilitate the interpretation of study findings to help you better design clinical trials.

SA-000431

We offer a fully integrated service with a multidisciplinary team in the field of musculoskeletal research, Charles RIver's scientists, pathologists, veterinarians, and surgeons offer technical expertise to assess accurately and efficiently the safety and efficacy of musculoskeletal drugs and devices in short- and long-term studies. This integrated approach allows for the comprehensive evaluation of bone, muscle, and cartilage drug efficacy and safety, muscle tissue healing and biocompatibility, orthopedic device efficacy, and the effects of new orthobiologic applications.

Research animal models are critical in understanding the human musculoskeletal system and diseases. Charles River offers the Lewis Rat, SHRSP Rat, and transgenic mouse and rat models to help further musculoskeletal disease research.

Basic Research Products and Services

Musculoskeletal disease comprises a number of chronic, debilitating conditions affecting millions globally. Some of these conditions, like osteoarthritis or sarcopaenia, become more prevalent with age, which puts the aging populations in many developed countries at higher risk, while others, like muscular dystrophies, are caused by genetic mutations, often appear early in life and can have profound effects on the mobility of those afflicted. While much progress has made recently in elucidating the molecular pathways that contribute to the development and progression of musculoskeletal disease, many challenges remain in drug discovery research in this field, including challenges associated with assessing disease stage, progression, and efficacy. Charles River helps accelerate your discoveries through innovative target identification and validation, complex in vitro and in vivo pharmacology models, and a strong chemistry and disease biology foundation, all of which assist in translating basic research to clinical reality.

New therapies to promote bone healing or treat osteoporosis, arthritis, and other musculoskeletal diseases require comprehensive assessments of bone and cartilage to ascertain efficacy. Endpoints including pathology, imaging, and biomechanical strength testing can be incorporated into study designs to fully evaluate a compound’s effect on the musculoskeletal system.

Charles River offers services in musculoskeletal research that combine established discovery and preclinical program development expertise with a host of novel bone research technologies to provide highly specialized evaluations of bone disease and bone quality. Our musculoskeletal research scientists can assess the effect of a drug in vivo or ex vivo on bone at toxicological and pharmacological doses and facilitate the interpretation of study findings to help you better design clinical trials.

Discovery Services

Charles River offers a fully integrated service with a multidisciplinary team in the field of musculoskeletal research. Our scientists, pathologists, veterinarians, and surgeons offer technical expertise to assess accurately and efficiently the safety and efficacy of musculoskeletal drugs and devices in short- and long-term studies. This integrated approach allows for the comprehensive evaluation of bone, muscle, and cartilage drug efficacy and safety, muscle tissue healing and biocompatibility, orthopedic device efficacy, and the effects of new orthobiologic applications. Our musculoskeletal research scientists can assess the effects of a drug in vivo or ex vivo on bone at toxicological and pharmacological doses and facilitate the interpretation of study findings to help you better design clinical trials.

Safety Assessment Products and Services

Our laboratory scientists use fully validated, networked data management systems at all laboratory locations for test article/item and sample management. We have made significant investments in highly trained chemists, facilities, and instrumentation to increase our capabilities and capacity to produce rapid and reliable quality data. Key services include formulation and analytical chemistry, bioanalysis HPLC, LC/MS/MS, ELISA and immunology.

General Support Products and Services