Oncology Tools & Resources
Like you, we believe there is a cure. Illustrating our mission and services in context, our dedicated oncology page is designed to be your single source destination for the latest data, resources, and success stories in our field. We invite you to take a deep dive into your topics of interest by browsing our collection of articles, blog posts, webinars, and more. Meet our scientific team, discover what motivates them, and learn about their areas of focus. Get instant access to data tools that can accelerate your research.
Success Stories
The right partner can help you win the race to reach patients first. From basic research to IND and every stage in between, we’re dedicated to helping you reach your goals. Our proven track record speaks for itself:
91%
Percentage of 2019 FDA-approved cancer therapies were developed with Charles River.
62
Oncology patents co-invented by our scientists.
16
Oncology candidates delivered to our partners.
2
Years from hit ID to candidate delivery.
Watch the webinar.
3
Charles River scientists describe the integrated approach for successful oncology R&D.
Read the feature.
Find the key to your success.
Oncology Services
Move at the speed of oncology with an integrated approach to development. Trust our team for efficient, cost-effective solutions that usher your therapy from early discovery all the way to the clinic.
Assay Development
Progress the early discovery phase of your research with help from a team that develops and executes more than 100 biochemical and cellular assays per year for an extensive range of target classes.High-Throughput Screening
Select the best screening approach, design and optimize an effective campaign, and identify quality hits with help from our experienced team.Virtual Screening
Expedite your hit ID, hit-to-lead and lead optimization for ADME and toxicology profiles with computer-aided (in silico) drug design.Large Molecule Screening
Discover, analyze, engineer, and own exclusive therapeutic antibodies using the antibody discovery platform from our partner, Distributed Bio.Medicinal Chemistry and Synthetic Chemistry
Make informed decisions from early discovery through your IND-enabling studies with data from our experienced drug discovery chemists.Pharmaceutical Sciences and Formulation
Elucidate the physical properties of your compound and ensure you move your best candidate forward with help from our pharmaceutics experts.ADME-PK
Drive development at every stage with rich DMPK ADME data – define potency against targets and optimize PK, validate toxicology and predict DDIs.High Content Imaging
Visualize and measure phenotypic changes at the subcellular level in disease relevant cell-based assays.In Vitro PDX Assays
Assess potency and selectivity, identify MoA vis COMPARE analysis, and analyze multi-drug resistance with PDX combination studies.3D Tumor Assays
Find the most promising candidates, tumor histotypes and molecular subtypes for further testing by evaluating the potency of your compound against SOC drugs.Immuno-Oncology Assays
Accelerate your development with specialized adaptive and innate immune assays, including T cell, immune-mediated tumor killing, macrophage, dendritic, NK, and tumor cell-based assays.Stem Cell Technology
Power your drug screening, biomarker discovery and evaluation of disease pathophysiology with custom human stem cell assays.CRISPR Gene Editing
Create complex custom knock-in and knock-out cell lines for target screening alone or alongside RNAi screening with our shRNA library.Pharmacodynamic Models
Confirm that your therapy is hitting its target and affecting cells the way you predict with pharmacodynamic models like graft vs. host and adoptive T cell transfer, and more.Xenograft Models
Test your therapy in a translational system with fully characterized syngeneic, orthotopic, cell line- and patient-derived xenografts.Humanized Models
Assess your cancer therapeutic in the context of a patient immune system in studies that employ immunodeficient mice, humanized tumor models, or humanized mice.Translational Support
Enrich your understanding with data that reflects clinical endpoints using advanced tools like noninvasive in vivo imaging, tumor microdialysis, and flow cytometry.Genetic Engineering
Design and create mouse models that suit your purposes with custom model creation and genetically engineered model breeding services.Research Model Services
Manage your animal colonies with help from our scientific staff support services, and protect your investment by screening biologics for contamination and infectious agents.Toxicology
Assess acute through chronic toxicity and carcinogenicity with our board-certified toxicologists, veterinary surgeons and pathologists, and regulatory specialists.