Oncology

Whether you are in basic research and discovery or ready to move your therapeutic into the clinical development phase, Charles River’s deep oncology expertise, global infrastructure, and unmatched portfolio of services are exactly what you need to advance your anticancer therapy to market. Offering support across the continuum from animal models to safety assessment and support for biologic therapies, Charles River strives to be your premier oncology partner.

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Microscopic electron image of breast cancer cells.

Oncology Tools & Resources

Like you, we believe there is a cure. Illustrating our mission and services in context, our dedicated oncology page is designed to be your single source destination for the latest data, resources, and success stories in our field. We invite you to take a deep dive into your topics of interest by browsing our collection of articles, blog posts, webinars, and more. Meet our scientific team, discover what motivates them, and learn about their areas of focus. Get instant access to data tools that can accelerate your research.

 


 

Success Stories

The right partner can help you win the race to reach patients first. From basic research to IND and every stage in between, we’re dedicated to helping you reach your goals. Our proven track record speaks for itself:

83%

Percentage of 2020 FDA-approved cancer therapies were developed with Charles River.

62

Oncology patents co-invented by our scientists.

16

Oncology candidates delivered to our partners.

2

Years from hit ID to candidate delivery.
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3

Charles River scientists describe the integrated approach for successful oncology R&D.
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Oncology Services

Move at the speed of oncology with an integrated approach to development. Trust our team for efficient, cost-effective solutions that usher your therapy from early discovery all the way to the clinic.

In vitro assay development using high content imaging for phenotypic screening in neuroscience research.

Assay Development

Progress the early discovery phase of your research with help from a team that develops and executes more than 100 biochemical and cellular assays per year for an extensive range of target classes.

Charles River drug discovery uses large compound libraries and high throughput screening (HTS) technology for the identification of hit compounds and assay development and offers high-throughput HTS screening services for high throughput screening in drug discovery including phenotypic screening, cellular assays, biochemical assays.

High-Throughput Screening

Select the best screening approach, design and optimize an effective campaign, and identify quality hits with help from our experienced team.

Hand touching a computer screen.

Virtual Screening

Expedite your hit ID, hit-to-lead and lead optimization for ADME and toxicology profiles with computer-aided (in silico) drug design.

Charles River and Distributed Bio partner to offer a humanized scfv antibody library used for antibody screening, antibody discovery and antibody engineering. Antibody discovery platforms include the Superhuman antibody library, Tumbler antibody optimization and Abgenesis for the analysis of antibody library data and antibody discovery data. This antibody development technology is phage display technology and ideal for G protein coupled receptors (GPCRs), ion channels and CAR-T applications.

Large Molecule Screening

Discover, analyze, engineer, and own exclusive therapeutic antibodies using the antibody discovery platform from our partner, Distributed Bio.

Scientist in a lab

Medicinal Chemistry and Synthetic Chemistry

Make informed decisions from early discovery through your IND-enabling studies with data from our experienced drug discovery chemists.

Researcher dropping the clear reagent into test tube with periodic table and chemical equations background, for reaction testing in chemical laboratory.

Pharmaceutical Sciences and Formulation

Elucidate the physical properties of your compound and ensure you move your best candidate forward with help from our pharmaceutics experts.

Pharmacokinetics is a key component of DMPK ADME studies. A male technician in safety gear reviews dosing and sampling of studies to determine the pharmacokinetic profile of promising compounds. Standard data generated includes time to Cmax, tmax, t1/2 elimination, and AUC.

ADME-PK

Drive development at every stage with rich DMPK ADME data – define potency against targets and optimize PK, validate toxicology and predict DDIs.

High Content Imaging using Multiplex Cell Painting. HeLa cells stained with six fluorescent dyes after exposure to Colchicine therapy.

High Content Imaging

Visualize and measure phenotypic changes at the subcellular level in disease relevant cell-based assays.
Human tumor cell lines derived from PDX Models, retain characteristics such as expression and mutation profiles, and are a valuable resource in cancer research.

In Vitro PDX Assays

Assess potency and selectivity, identify MoA vis COMPARE analysis, and analyze multi-drug resistance with PDX combination studies.

Charles River offers ex vivo Anti-Tumor Efficacy Screens using 3D Tumor Models.

3D Tumor Assays

Find the most promising candidates, tumor histotypes and molecular subtypes for further testing by evaluating the potency of your compound against SOC drugs.

Illustration of the Tumor microenvironment.

Immuno-Oncology Assays

Accelerate your development with specialized adaptive and innate immune assays, including T cell, immune-mediated tumor killing, macrophage, dendritic, NK, and tumor cell-based assays.

Image of stem cells such as functional engineered human cells iPS cells are used to develop custom cell-based assays for drug screening.

Stem Cell Technology

Power your drug screening, biomarker discovery and evaluation of disease pathophysiology with custom human stem cell assays.

illustration of genetic engineering and gene manipulation used in CRISPR Cas 9 technology

CRISPR Gene Editing

Create complex custom knock-in and knock-out cell lines for target screening alone or alongside RNAi screening with our shRNA library.
The immune system fighting cancer cells- Charles River has a range of immune-oncology models and assays.

Pharmacodynamic Models

Confirm that your therapy is hitting its target and affecting cells the way you predict with pharmacodynamic models like graft vs. host and adoptive T cell transfer, and more.

Syngeneic mouse models involve implantation of mouse tumor tissue into mice with the same genetic background, allowing cancer immunotherapies to be tested in an intact immune system.

Xenograft Models

Test your therapy in a translational system with fully characterized syngeneic, orthotopic, cell line- and patient-derived xenografts.

humanized mice are immunodeficient models used in studies for immuno-oncology and infectious disease research.

Humanized Models

Assess your cancer therapeutic in the context of a patient immune system in studies that employ immunodeficient mice, humanized tumor models, or humanized mice.

Metastasis of cancerous cell

Translational Support

Enrich your understanding with data that reflects clinical endpoints using advanced tools like noninvasive in vivo imaging, tumor microdialysis, and flow cytometry.

White mouse with test tubes

Genetic Engineering

Design and create mouse models that suit your purposes with custom model creation and genetically engineered model breeding services.

Scientific staffing for laboratory animal science

Research Model Services

Manage your animal colonies with help from our scientific staff support services, and protect your investment by screening biologics for contamination and infectious agents.
Toxicology studies supporting preclinical drug, chemical, and device development programs conducted under GLP regulations.

Toxicology

Assess acute through chronic toxicity and carcinogenicity with our board-certified toxicologists, veterinary surgeons and pathologists, and regulatory specialists.

Discover the Charles River safety pharmacology services that helps to support your drug development program.

Safety Pharmacology

Assess how your therapeutic affects physiological function across key systems with our ICH core battery and supplementary safety tests.

Scientist in a lab.

Laboratory Sciences

Supplement your in-house capabilities or outsource your entire program to our extensive network of analytical laboratory facilities.

DMPK ADME Studies

DMPK

Characterize the ADME properties of your test articles throughout development with in vitro and in vivo drug metabolism and pharmacokinetic studies.

Charles River offers preclinical imaging and in vivo imaging solutions for drug and device developers, such as radiochemistry, which is an important aspect of imaging for preclinical studies to know the correct radioisotope for specific chemical entities.

Molecular imaging and Radiochemistry

Evaluate your therapy’s exposure and binding to the target of interest and confirm expression of the desired pharmacology with early stage molecular imaging.

Pathologist examining histopathology slide

Pathology Services

Gain insight to your therapy’s safety, efficacy, and MoA with anatomic and clinical pathology endpoints delivered by our expert veterinary pathologists.
Bioanalytical services include careful preparation of reference standards for a validated bioanalytical method standard curve to quantitate biological samples for drug concentrations in both clinical and preclinical bioanalysis.

Bioanalytical Services

Make confident research decisions from method development to clinical sample analysis with our accurate, reliable and efficient bioanalytical services.

Clinical Biomarker Lab for PD Biomarker Assay.

Clinical Biomarkers

Maximize your clinical budget with early phase biomarker data that drives your decision to progress further into trials.

scientist working in biologic drug development testing lab

Biologics Testing Solutions

Test your oncology antibodies, vaccines, cell and gene therapies and biosimilars in preparation for market with our robust GMP manufacturing services.