Despite extensive research, understanding neuropathic pain underlying mechanisms is far from complete and exposes a profound need for developing novel therapies. However, the animal models of pain have recently attracted criticism due to low translational value.
In the first of our two-part pain series, we address the criticism levied at the current models and suggest a collection of a broader range of readouts besides those related to pain behaviors that will increase their utility and translatability. Several rodent models of neuropathic pain, focusing on surgical mononeuropathy and chemotherapy-induced polyneuropathy (CIPN) are discussed. We also present examples of tailored models and delivery routes in pursuit of specific molecular targets or pathways that could potentially be used to treat peripheral neuropathic pain.
Anna-Mari Kärkkäinen, MSc
Study Director, CNS In Vivo Pharmacology
View the other webinar in the series:
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