AACR 2020 Poster Resources

AACR Virtual Annual Meeting II, June 22-24, 2020

Use the tabs below to explore our range of posters, ePosters and resources from AACR 2020. Or find previous years posters at www.charlesriveroncology.com. Patients are waiting. We'll keep moving at the speed of oncology.

Our scientists, in collaboration with our partners, proudly presented 19 scientific posters at AACR 2020. You can download poster presentations below covering a variety of research topics, or click on the ePoster Presentations tab to watch the poster videos.

 

Antibody Technologies

Advanced Engineering Using CAR-T Display Libraries: Ultra-High Throughput Functional Screen
Distributed Bio in Collaboration with Charles River

Experimental and Molecular Therapeutics

Co-administration of iRGD and therapeutic EGFR-antibodies Cetuximab and Panitumumab enhances drug penetration in NSCLC PDX based 3D multicellular spheroids
Julia Schueler, Charles River

Immunology

ePoster Presentation Available
A panel of NSCLC patient derived xenografts displays a distinct sensitivity profile towards checkpoint inhibitor treatment in vitro and in vivo

Robert Nunan, Charles River

ePoster Presentation Available
An integrated in vitro and in vivo approach providing insights in immune modulation

Shilina Roman, Charles River

ePoster Presentation Available
Enhanced anti-tumor lymphocyte function and frequencies measured by multichromatic flow cytometry in human CTLA-4 knock-in mice in a colorectal carcinoma model after treatment with ipilimumab

Elizabeth Reap, Charles River

ePoster Presentation Available
Evaluation of in vivo anti-tumor response of solid tumors in a novel immune cell-humanized NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl mouse model

Jenny Rowe, Charles River

HPK1, Hematopoietic Progenitor Kinase 1, is a Promising Therapeutic Target for Cancer Immunotherapy
Nimbus Therapeutics in Collaboration with Charles River

ePoster Presentation Available
In vitro cell based cytotoxicity and T cell activation assays to assess safety and efficacy of engineered T cell therapies

Sanne Holt, Charles River

Potent oral ERAP1 inhibitors modify the immunopeptidome in vivo and are novel immunotherapy agents
Grey Wolf Therapeutics in Collaboration with Charles River

ePoster Presentation Available
The single mouse trial format predicts the sensitivity towards checkpoint inhibitor treatment in NSCLC PDX models in HuCD34NCG/CRL mice, an innovative triple immune deficient mouse strain

Julia Schuler, Charles River

Tumor Biology

ePoster Presentation Available
A mouse orthotopic model of pancreatic cancer and response to treatment

Elizabeth Rainbolt, Charles River

A preclinical model using perfusion air culture of tumor tissue slices for personalized medicine
IKP in Collaboration with Charles River

ePoster Presentation Available
A translational immuno-oncology platform to model T cell activation and Tex recovery in the tumor microenvironment

Robert Nunan, Charles River

ePoster Presentation Available
In vitro tumor killing assays for predicting cellular therapeutic efficacy

Robert Nunan, Charles River

Interplay between γδ T cells and breast cancer stem cells- a matter of life and death
University of Alberta in Collaboration with Charles River

ePoster Presentation Available
Longitudinal characterization of patient-derived orthotopic xenograft brain tumor models

Julia Schuler, Charles River

ePoster Presentation Available
Tumor models driven by EGFR: Optimizing the preclinical profiling of EGFR-targeting agents

Thomas Metz, Charles River

Zebrafish patient tumor-derived xenograft models synergize with mouse-PDX models for understanding variation in anti-cancer drug responses
BioReperia In Collaboration with Charles River

Zebrafish patient tumor-derived xenograft models used for pre-clinical evaluation of CAN04 for lung and pancreatic cancer
BioReperia In Collaboration with Charles River

Featured ePoster
An Integrated In Vitro and In Vivo Approach Providing Insights in Immune Modulation

Presented by Shilina Roman, Associate Director Integrated Biology

Download the PDF

 

Featured ePoster
In Vitro Cell Based Cytotoxicity and T Cell Activation Assays to Assess Safety and Efficacy of Engineered T Cell Therapies

Presented by Sanne Holt, Group Leader, Biology

Download the PDF

 

Featured ePoster
Longitudinal Characterization of Patient-Derived Orthotopic Xenograft Brain Tumor Models

Presented by Tuulia Huhtala, Head of Biomarkers

Download the PDF

 

A translational immuno-oncology platform to model T cell activation and Tex recovery in the tumor microenvironment

Download the PDF

 

In vitro tumor killing assays for predicting cellular therapeutic efficacy

Download the PDF

 

A mouse orthotopic model of pancreatic cancer and response to treatment

Download the PDF

 

Evaluation of in vivo anti-tumor response of solid tumors in a novel immune cell-humanized NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl mouse model

Download the PDF

 

A Panel of NSCLC patient derived xenografts displays a distinct sensitivity profile towards checkpoint

Download the PDF

 

PDX models driven by EGFR Optimizing the preclinical profiling of EGFR targeting agents

Download the PDF

 

The single mouse trial format predicts the sensitivity towards checkpoint

Download the PDF

 

Enhanced anti-tumor lymphocyte function and frequencies measured by multichromatic flow

Download the PDF

In the research community, we know our work doesn’t stop when crisis hits. Keep yours going strong with this collection of insights, tools, and resources prepared by our team. Or, take a deep dive into our comprehensive portfolio of oncology research models, tools, and services at www.charlesriveroncology.com.

On-Demand Webinars

zebrafish swimming in aquarium

A New Translational In Vivo Tool for Oncology Drug Discovery: Zebrafish Tumor Xenograft Model
Presented by: Julia Schüler, DVM, PhD, Research Director, Charles River
Anna Erkstam, PhD, Chief Operating Officer (COO), BioReperia AB
Lasse Jensen, PhD, Chief Technical Officer (CTO) and Co-Founder, BioReperia AB

 

microscopic image of breast cancer cells

Catching Patient Diversity In Vitro: PDX-based Assays in Oncology Drug Discovery
Claudia Göttlich, PhD, Study Director, In Vitro, Charles River

 

medically accurate 3d illustration of cancer cells.

When Immune Cells Invade a Tumor: Using the TME to Drive Your Oncology Research
Presented by: Robert Nunan, PhD, Group Leader, Charles River

 

micro electron image of breast cancer cells.

Emergent Humanized Mouse Models Are Driving Immuno-Oncology Strategy
Presented by: Paula Milinani de Marval, PhD, Associate Research Director, Discovery Services, Charles River

 

composition of tumor microenvironment

Microdialysis: A Novel Tool to Sample the Tumor Microenvironment
Presented by: Nadege Morisot, PhD, Senior Scientist, In Vivo Pharmacology Charles River

 

Glioblastoma Model imagaing

Preclinical Imaging: A Translational Approach to Assess New Cancer Treatments
Presented by: Tuulia Huhtala, PhD, Head of Biomarkers and Molecular Imaging, Charles River

 

Computer generated abstract fractal illustration of a virus in human body.

How to Design & Execute Successful CAR-T Cell Therapy Programs (Available in The Source℠)
Presented by: David Harris, PhD, Research Director, Oncology, Charles River

 

3D illustration of DNA helix connected by nodes and connections.

Bioinformatics: Mining Big Data to Discover Precision Oncology Therapies
Presented by: Max Bylesjo, PhD, MSc, Technical Director, Fios Genomics

 

 

Tools

 

 

Blogs

 

 

 

Podcast

Tumor Cell.

Sounds of Science
Episode 20: A Tumor's Lair