ApoE Knockout Mouse (JAX™ Mice Strain)

B6.129P2-Apoetm1Unc/J
Genetically Engineered
Inbred
ApoE JAX Mouse
Breeding Location

ApoE Knockout Mouse (JAX™ Mice Strain) Details

The Apoetm1Unc mutant strain was developed in the laboratory of Dr. Nobuyo Maeda at The University of North Carolina at Chapel Hill. The 129-derived E14Tg2a ES cell line was used. The plasmid used is designated as pNMC109 and the founder line is T-89 in the primary reference. The strain was produced by backcrossing the Apoetm1Unc mutation 10 times to C57BL/6J mice. Pedigree mice from The Jackson Laboratory were transferred to Charles River Laboratories UK in October 2004.

Coat Color
Black

Strain Code
622

Ideal For
Cardiovascular research (atherosclerosis, heart abnormalities, hypercholesterolemia, hypertriglyceridemia, vascular defects)

JAX-ApoE%20Italy%20Growth%20Chart.jpg

Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.

ApoE Knockout Mouse (JAX™ Mice Strain) Details

The Apoetm1Unc mutant strain was developed in the laboratory of Dr. Nobuyo Maeda at The University of North Carolina at Chapel Hill. The 129-derived E14Tg2a ES cell line was used. The plasmid used is designated as pNMC109 and the founder line is T-89 in the primary reference. The strain was produced by backcrossing the Apoetm1Unc mutation 10 times to C57BL/6J mice. Pedigree mice from The Jackson Laboratory were transferred to Charles River Laboratories UK in October 2004.

Coat Color
Black

Strain Code
622

Ideal For
Cardiovascular research (atherosclerosis, heart abnormalities, hypercholesterolemia, hypertriglyceridemia, vascular defects)

Growth Chart for JAX™ ApoE Mice at CRL Japan

For additional information, including pricing details, please visit the B6.129P2-Apoetm1Unc/J mouse page on the Charles River Japan website.

JAX™ MICE AND RESEARCH SERVICES


Charles River is the exclusive distributor of JAX™ Mice and select research services in Europe, Japan, Korea, and Taiwan.
 

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JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
 

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Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.

This mouse model is part of the Jackson Laboratory patented Genetic Stability Program (GSP). Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.

 

TECHNICAL RESOURCES

A Charles River-Hosted JAX Webinar™:
Comparing Mouse Models for Obesity and Diabetes Research

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Want to learn about the strengths and weaknesses of the most popular mouse models of human type 2 diabetes and obesity?

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