ApoE Knockout Mouse (JAX® Mice Strain) Details
Mice homozygous for the Apoetm1Unc knock-out mutation show a marked increase in total plasma cholesterol levels that are unaffected by age or sex. Fatty streaks in the proximal aorta are found at three months of age. The lesions increase with age and progress to lesions with less lipid but more elongated cells, typical of a more advanced stage of pre-atherosclerotic lesion. These ApoE KO mice are useful for studying cardiovascular disease, atherosclerosis and fat metabolism, as well as the role of ApoE in Alzheimer's disease. Pedigree mice from The Jackson Laboratory were transferred to Charles River Laboratories UK in October 2004.
Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.
UNIT: 3
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JAX® Mice and Research Services
Charles River is the exclusive distributor of JAX® Mice and select research services in Europe, Korea, and Taiwan.
JAX® is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
This mouse model is part of the Jackson Laboratory patented Genetic Stability Program (GSP). Only The Jackson Laboratory and Charles River in Europe maintains colonies of JAX® Mice strains, which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.
ApoE Knockout Mouse Resources
- Characteristics of JAX® ApoE Knockout Mice
- Mouse Phenome Database: JAX® ApoE Knockout
- A Charles River-Hosted JAX® Webinar: Comparing Mouse Models for Metabolic Disease – Diabetes, Obesity, and MASH
- Whitepaper: Strategies to Minimize Genetic Drift and Maximize Experimental Reproducibility in Mouse Research