NOD Mice (JAX® Mice Strain) Details
The NOD/ShiLtJ strain (commonly called NOD) is a polygenic model for autoimmune type 1 diabetes. Diabetes in NOD mice is characterized by hyperglycemia and insulitis, a leukocytic infiltration of the pancreatic islets. Marked decreases in pancreatic insulin content occur in females at about 12 weeks of age and several weeks later in males. A 2022 phenotyping study found that 86% of females and 48% of males became diabetic by 30 weeks of age; median female incidence was 18 weeks. Immune phenotypes in the NOD background consist of defects in antigen presentation, T lymphocyte repertoire, NK cell function, macrophage cytokine production, wound healing, and C5 complement. These defects make the NOD background a common choice for immunodeficient mouse strains.
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JAX® Mice and Research Services
Charles River is the exclusive distributor of JAX® Mice and select research services in Europe, Korea, and Taiwan.
JAX® is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
This mouse model is part of the Jackson Laboratory patented Genetic Stability Program (GSP). Only The Jackson Laboratory and Charles River in Europe maintain colonies of JAX® Mice strains, which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.