1H-MRS and 31P-MRS in CNS Drug Development

Charles River has implemented pulse sequences for localized 1H-MRS, enabling quantitative determination of 15-18 metabolite concentrations that is detected using LCModel software. Our imaging team offers 31P MRS to detect changes in energy metabolism including ATP, phosphocreatine, and inorganic phosphate.

Image gallery: 1H-MRS in aged female Fisher rats and Alzheimer’s disease mouse models. In both models, N-acetyl aspartate and Glutamate are decreased while myo-inositol is increased.

MRS Frequently Asked Questions (FAQs)