Why Buy Disease State Biospecimens?
Valuable insights into disease etiology can be gained by comparing the various properties of biospecimens from patients with specific diseases versus healthy samples. For example, disease state apheresis can be used to assess the applicability of a cell therapy development process to the disease state of interest, as disease state biospecimens have inherent differences that may affect both the process and final therapeutic.
Furthermore, disease state peripheral blood mononuclear cells can be used in the development of antigen specific T cells against disease associated epitopes. Disease state biospecimens, especially diseased primary cells, will enable advancements in gene editing, immunology, and cellular therapy leading to groundbreaking medical discoveries for life-threatening diseases.
Lineage of CD34+ Hematopoietic Stem and Progenitor Cells (HSPCs)
Receive a complimentary poster to access information on immune cell markers, differentiation factors, cytokines, technical protocols, media recommendations, how-to videos, and more.
Available Disease State Biospecimens
Our customized Disease State Program provides you with access to the following patient disease state biospecimens collected under an IRB-approved protocol. There’s also the option to request custom collections that meet your specific Inclusion/Exclusion (I/E) criteria. Each customized sample comes with a comprehensive report detailing the targeted disease history, treatment, I/E compliance, and demographic profile.
| Apheresis-Derived Immune Cells | Leukopaks, PBMCs, and isolated cells |
| Blood-Derived Products | Whole blood, serum, and plasma |
| Bone Marrow-Derived Products | Bone marrow aspirate and isolated cells |
| Cancer-Derived Biospecimens | Tumor biopsy and malignant effusions |
| Other Disease State Product Types | Mucus membrane swabs and urine are available upon request |
List of Diseases Covered Under Our IRB Approval
Our customized Disease State Program covers a comprehensive list of diseases including:
| Autoimmune/Immune-Mediated Disorders | Multiple Sclerosis, Systemic Lupus Erythematosus, Celiac Disease, Diabetes Mellitus (DM) - Type 1 and Type 2 |
| Cardiovascular Disease | Peripheral Artery Disease, hypercholesterolemia, hypertension, Metabolic Syndrome (heart disease, obesity, diabetes) |
| Hematologic Malignancies (blood cancers) | Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Multiple Myeloma |
| Infectious Diseases | Viruses, some STDs |
| Integumentary (Skin) Diseases/Disorders | Psoriasis, alopecia, vitiligo (loss of skin pigmentation) |
| Musculoskeletal Disease/Disorders | Osteoarthritis, fibromyalgia, osteoporosis, myositis |
| Neurological Diseases | Movement disorders, MS, some seizure disorders |
| Non-Hematologic Malignancies | Colorectal cancer, sarcomas (muscle and bone tumors), testicular cancer, breast cancer, melanoma |
| Other Diseases and Conditions | Hormonal conditions – menopause, Cushing’s Syndrome, parathyroid disorders |
| Renal Diseases | Lupus nephritis, Polycystic Kidney Disease |
Transform Your Disease State Research
Gain access to our custom Disease State Program, full range of expert services, and Research Use Only (RUO) products to accomplish your project objectives and ensure success. Request a quote
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Comprehensive Patient-Outreach Methods
We'll work on your behalf to design strategic campaigns recruiting eligible patients meeting your required I/E criteria – thus ensuring the success of your research objectives.
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Unparalleled Patient Care and Management
We take a thoughtful and transparent approach when building our patient populations and normal healthy donor cohorts.
- Patient safety – Implementing strict patient management practices overseen by medical directors to ensure patient safety
- Patient eligibility – Conducting comprehensive screenings to ensure safety and adherence to I/E criteria
- Medical provider consultations – Communicating with medical providers to confirm patient diagnosis and appropriateness of patient participation
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Comprehensive Testing
We take added measures to provide a targeted and holistic view of the patient’s health, to safeguard the patient’s well-being during participation.
- Comprehensive Infectious Disease panel testing based on FDA-approved screening
- Complete Blood Count (CBC) with five-part differential testing
- Comprehensive Metabolic Panel testing (minimum of 14 tests to assess organ system function)
- Disease-associated biomarkers (as requested)
- Serum pregnancy test performed on birth females of childbearing age
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Detailed Diagnosis Summary Report
Obtain a tailored summary report confirming specified patient eligibility criteria are met, to help you achieve project goals in a timely manner. Comprehensive Infectious Disease panel testing based on FDA-approved screening
- Diagnosis documentation confirmation
- I/E criteria confirmation
- History of targeted disease/disorder treatment and medication/therapy regimen
- Targeted lifestyle practices confirmation
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Where are patient disease state biospecimens collected from?
We have a patient donor center located in Los Angeles. Our patient care teams comprised of physicians, advanced practice providers, registered nurses, and patient advocates bring decades of experience in outpatient and acute care patient settings, including:
- Customized donor recruitment and screening services under IRB-approved protocols
- Autologous collection services
- Allogeneic collection services
- Donor center that is FDA-registered, AABB-certified, and state-licensed, providing a continuous supply of raw starting materials to help scale-up work and meet research needs
- Access to a large, diverse, highly characterized, and recallable donor network to find the right donor in less time and to support even the most stringent inclusion and exclusion project criteria
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Can researchers request custom collections that meet specific Inclusion/Exclusion criteria?
Absolutely. At Charles River, we understand that every project is unique. Therefore, we offer the option to request custom collections that meet your specific Inclusion/Exclusion (I/E) criteria. This personalized approach allows you to have the exact samples needed for your project. Our team will work closely with you to understand your requirements and provide tailored solutions to meet your project goals.
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Are your patient disease state collections conducted under an IRB-approved protocol?
Yes, all patient disease state biospecimens are obtained under an IRB-approved protocol. This ensures that all collections are conducted ethically and in compliance with regulatory guidelines.
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How does Charles River ensure the safety of patients participating in studies?
At Charles River, we understand the importance of safety for patients participating in studies. That is why we have taken added measures to provide a targeted and holistic view of each patient's health. Our Comprehensive Infectious Disease panel testing uses FDA-approved screening to identify any potential infectious diseases that could affect the patient's well-being during the study.
Additionally, our (CBC) with five-part differential testing and Comprehensive Metabolic Panel testing give a comprehensive look at the patient's blood levels and overall health. We also offer disease-associated biomarkers, which can provide valuable insights into any underlying conditions that could impact the patient's participation in the study. And for birth female patients, we offer serum pregnancy tests to ensure their safety during participation.
At Charles River, we prioritize the safety and well-being of our patients above all else and take every precaution necessary to ensure their health is safeguarded throughout their participation.