EEG Monitoring

We use Electroencephalogram (EEG) monitoring to assess changes in sleep state and electrical activity associated with neurological disease models. Using a telemetric approach, EEG patterns indicative of changes in underlying neuronal function are recorded and show specific rhythmic activity that can be used as characteristic translational biomarkers. Noninvasive EEG measurements are easily combined with other techniques like behavior testing and microdialysis. Understanding the effects of test compounds on the activity and function of the brain are essential in drug development, and Charles River can perform continuous EEG following acute or chronic compound treatment in combination with PK/PD studies and behavioral testing.

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EEG Services

  • Sleep-Wake Monitoring

    Understanding sleep patterns is essential in drug development. With our telemetry approaches, we can continuously monitor sleep activity and the effects of novel therapeutics on sleep patterns using the following assay readouts:

    • Quantitative EEG with spectral analysis
    • Wake
    • Slow wave sleep (SWS)/Non-rapid eye movement (NREM) sleep
    • Paradoxical sleep (PS)/Rapid eye movement (REM) sleep
    • Acute monitoring
    • Chronic monitoring
    • Seizure detection
  • Seizure Detection

    Seizures are a hallmark of a dysfunctional brain. They can be caused by brain trauma, induction of noxious chemicals, in some cases therapeutic agents, and disorders such as epilepsy. This makes understanding seizure activity essential to understanding brain function and the function of novel therapeutics. We use telemetry, alone or in combination with other techniques, such as simultaneous video tracking, to monitor seizure activity. Our capabilities include:

    • Acute seizure detection
    • Chronic seizure monitoring
    • Simultaneous video tracking
    • Behavioral scoring
    • Combination with microdialysis
    • Pharmaco-EEG

     

    Figure 1: Seizure Detection

     

    EEG readouts showing the effect of kainic acid-induced seizures

    Baseline and effect of kainic acid-induced seizures are shown on the EEG readouts.

  • Pharmaco-EEG

    Understanding the effects of test compounds on the activity and function of the brain are essential in drug development. We are able to perform continuous EEG following acute or chronic compound treatment. Capabilities include:

    • Acute treatment
    • Chronic treatment
    • Combination with PK, PD, or behavior