NCG Mouse

NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl
Coisogenic
Immunodeficient
NCG Mouse
NCG Mouse
NCG Mouse

NCG Mouse Details

Co-developed by Nanjing Biomedical Research Institute of Nanjing University and Nanjing Galaxy Biopharma in 2014 and transferred to Charles River in 2016. This model was created by sequential CRISPR/Cas9 editing of the Prkdc and Il2rg loci in the NOD/Nju mouse, generating a mouse coisogenic to the NOD/Nju. The NOD/Nju carries a mutation in the Sirpa (SIRP α) gene that allows for engrafting of foreign hematopoietic stem cells. The Prkdc knockout generates a SCID-like phenotype lacking proper T-cell and B-cell formation. The knockout of the Il2rggene further exacerbates the SCID-like phenotype while additionally resulting in a decrease of NK cell production.

Humanize Your NCG Mouse Model

Note: Available for North American customers only

Coat Color
White (albino)

Strain Code
572

Ideal For
Oncology, immunology, infectious disease, graft vs. host disease, diabetes, regenerative medicine and human organ transplantation

Bred in