NCG Mouse

NOD-Prkdcem26Cd52Il2rgem26Cd22/NjuCrl
Coisogenic
Immunodeficient
The NCG mouse model is best suited for tumor and immunology studies
Breeding Location

NCG Mouse Details

NCG mice are triple immunodeficient and lack functional/mature T, B, and NK cells, and have reduced macrophage and dendritic cell function. These animal models have the ability to host xenograft cells, tissue, and human immune system components. The characteristics of NCG mouse models make them ideal for research on immuno-oncology, tumor biology, infectious disease, graft-versus-host disease (GvHD), hematopoiesis, and tissue transplant studies.

The NCG mouse is the foundation for the Charles River Hu-Mouse™ portfolio.


 
Humanize your NCG mice for oncology research


Give Your Study a Human(ized) Touch

Learn how using humanized NCG mouse models can improve the effectiveness of your immuno-oncology studies.

Advance Your Program


Co-developed by Nanjing Biomedical Research Institute of Nanjing University and Nanjing Galaxy Biopharma in 2014 and transferred to Charles River in 2016. The NCG mouse model was created by sequential CRISPR/Cas9* editing of the Prkdc and Il2rg loci in the NOD/Nju mouse, generating a mouse coisogenic to the NOD/Nju.

The NOD/Nju carries a mutation in the Sirpa (SIRP α) gene that allows for engrafting of foreign hematopoietic stem cells. The Prkdc knockout generates a SCID-like phenotype lacking proper T-cell and B-cell formation. The knockout of the Il2rg gene further exacerbates the SCID-like phenotype while additionally resulting in a decrease of NK cell production. This mouse model is ideal for oncology, immunology, infectious disease, graft-versus-host disease (GvHD), diabetes, regenerative medicine, and human organ transplantation. The NCG mouse model can also be utilized to create humanized mice by engrafting PBMCs or CD34 stem cells to closely mimic the human immune system.

Humanize Your NCG Mouse Model

Explore Our NCG Mouse Portfolio

Note: NCG mice available in North America only.
See our isolator page for available immunocompromised animal housing units.
**CRISPR/CAS9 used under licenses to granted and pending US and international patents from The Broad Institute and ERS Genomics Limited.

Coat Color
White (albino)

Strain Code
572

Ideal For
Oncology, immunology, infectious disease, graft vs. host disease, diabetes, regenerative medicine and human organ transplantation

Growth chart not available.

LOCATION: Hollister
UNIT: H45
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LOCATION: Wilmington
UNIT: W08
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Resources

 

Frequently Asked Questions (FAQs) about the NCG Mouse Model