Advanced Tools for Precision Bioanalysis

Bioanalytical platforms and techniques help overcome complex drug development challenges by delivering high-quality, reproducible data with speed and precision. Our expert teams leverage decades of experience along with a comprehensive suite of assays to support your program from discovery to market, enabling confident decisions at every stage. Cutting-edge methodologies and robust validation processes ensure fit-for-purpose results that meet evolving regulatory demands and reduce risk.

Our Core Bioanalytical Platforms

LC-MS

Offers unparalleled sensitivity and precision for nonclinical and clinical bioanalytical data.

Ligand Binding Assay

Used to detect and quantify biotherapeutics, biomarkers, and anti-drug antibodies.

Nonclinical Flow Cytometry

Offers advanced conventional and spectral platforms, expert assay design, and global support from discovery to the clinic.

Clinical Flow Cytometry

Multi-color flow cytometry for in-depth characterization of cell populations and immune responses in clinical trials.

Multiplex Cytokine Assays

Simultaneous quantification of numerous cytokines in a single sample for comprehensive immune response assessment.

qPCR Gene Expression Profiling

Highly sensitive quantitative PCR for detecting subtle changes in biomarker expression and gene qualification.

ELISpot Assays

Highly sensitive immunoassays assessing antigen-specific T and B cell responses in nonclinical and early-phase clinical trials.

NanoString RNA Analysis

Gene expression profiling technology offering low-bias, high-quality data for MOA and target engagement.

Talk to an Expert

digital rendering of antibody drug conjugate

Bioanalytical Strategies Unlocked: Innovative Approaches to PK, Immunogenicity, and Biomarkers
In this webinar, our scientific experts will walk you through real-world case studies that illustrate how innovative bioanalytical approaches can help you overcome common hurdles in pharmacokinetics (PK), immunogenicity, and biomarker applications.
Watch the Replay

Scientific illustration showing pink-orange antibody molecules interacting with blue chemical structures, a pink and blue DNA double helix, and glowing blue cellular clusters, representing molecular biology and biochemical processes.

eGuide: Bioanalysis from Early-Stage to Clinical Drug Development
Accounting for modality complexity, evolving regulatory expectations, and the critical importance of upfront planning, this eGuide explains how to identify risks early and align your bioanalytical strategy with the needs of your compound, your timeline, and your team.
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Frequently Asked Questions (FAQs) About Bioanalytical Platforms and Techniques

  • How does Charles River ensure bioanalytical data reliability?

    We ensure that the bioanalytical platforms we use are all 21 CFR Part 11 compliant and are subjected to rigorous Computer System Validation prior to utilization in a regulated environment. 

    We adhere to strict QC processes, regulatory guidelines (including GLP & GCP), and intensive fit for purpose method validation. Our workflows are optimized to ensure data integrated throughout the entirety of the study lifecycle. Globally harmonized process ensure consistent data transfer delivering robust, reliable, and reproducible data to enable informed decision-making.

  • What sample types are analyzed by your platforms?

    We have extensive experience in using our analytical platforms with a diverse range of biological samples, including blood (whole blood, plasma & serum), PBMCs, tissues, cultured cells, and cell-free samples such as CSF. Our scientific experts can provide advice and guidance to select the appropriate matrix & platform.

  • What is the typical timeline for starting a bioanalysis project with your team?

    We offer rapid start times for our bioanalytical services, with methodologies optimized to increase efficiency. The exact timeline can vary depending on the specific requirements of your project, but our dedicated team works diligently to meet critical deadlines and ensure timely delivery of results.

  • Do your services support early discovery and clinical trials?

    Yes, our services span the entire lifecycle of drug development, from early discovery and candidate selection, through IND-enabling toxicology studies, to all clinical trial phases. Services are tailored to meet both scientific and regulatory requirements at every stage.

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