Unraveling the Complexities of Cancer
We have contributed to 87% of FDA-approved cancer therapies in 2023. We let the numbers speak for themselves as our history of success includes 82 patents, 19 clinical candidates and 15 FDA-approved cell and gene therapies.
Explore our AACR Annual Meeting 2024 posters and resources below to learn more about how our comprehensive, integrated oncology portfolio can help you.
| Sunday, April 7, 2024 |
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| 1:30 p.m. - 5:00 p.m. | Section 1 Poster #22: Development and characterization of human tumor specific cytotoxic lymphocytes for preclinical drug development Julia Schueler, Charles River |
| 1:30 p.m. - 5:00 p.m. | Section 9 Poster #240: Mix and match - A comprehensive pipeline for matched patient-derived PDX and PD3D® models for cancer research and preclinical drug development Charles River in collaboration with CELLphenomics |
| 1:30 p.m. - 5:00 p.m. | Section 29 Poster #723: Reduction of immunosuppressive function of regulatory T cells enhances antigen-specific T cell mediated cytotoxicity against tumor cells Arif Khan, Charles River |
Sunday, April 7, 1:30 p.m. - 2:30 p.m.
PDX: Predictive Tumor Models to Accelerate your Preclinical Research In Vivo, In Vitro and In Silico 
PDX retain the histological and genetic characteristics of the donor tumor and remain stable across passages. They preserve cell-autonomous heterogeneity, thereby representing the molecular landscape of the corresponding disease. This session at the AACR annual meeting will give an overview of PDX in general and dive into different drug testing platforms and formats using PDX as sourcing material, such as:
- PDX 3D assays, to combine the advantages of clinically relevant, unlimited, and well annotated tumor tissue with a fully human microenvironment.
- PDX Digital Twin, as an initial screening tool for tumor type selection prior to running a refined in vivo study resulting in faster study results with higher predictive power.
Speakers:
Isabelle Caffry, Senior Director of Strategy and Corporate Development, Aitia
Julia Schueler, Therapeutic Area Lead, Charles River
Kolin Hribar, CEO, Cypre
ONCOLOGY TOOL
Apollo™ Oncology Price Estimator
Ready to validate your target? Generate an instant Oncology pricing with the Apollo™ Price Estimator. Let’s see how the users speak about this new tool: “This saves our team a lot of time; we get an idea of pricing without any back-and-forth communication” – Sciences Project manager, Pharma.
ONCOLOGY TOOL
Cancer Model Database
Explore our comprehensive Cancer Model Database and let the right models speed up your oncology discovery. This database gives you fast, self-service model research with quality data covering gene expression, mutations, copy number variations, or tumor metadata of fully characterized models, with experts ready to support you.
BLOGS
AACR Annual Meeting 2024 - Eureka Blogs
Explore Charles River's Eureka Blog series that highlights all the recent advances in drug development, and various insights from our scientists. This includes topics like 3D models, the future of biomarker discovery, advances in CAR therapeutics and much more.
ON-DEMAND
Pediatric PDX Models and RACE Act Webinar
With recent updates to FDA legislation, all oncology related drug development must be evaluated in pediatric models. View our webinar that discusses the RACE act and how Charles River, as part of the ITCCP4 consortium, can provide over 200 annotated, well-characterized, and RACE-compliant pediatric PDX models to accelerate your time to clinic. Learn more about the pediatric PDX models here.
CATALOG/PRICE LIST
2024 Cell Solutions Human and Stem Cells Product Catalog
Charles River is a trusted provider of human immune cells for cell and gene therapies and basic research. Download our 2024 catalog to learn more about our client-focused solutions and best-in-class portfolio of fresh and cryopreserved research use and GMP-compliant human immune cells.
VIDEO
Learn How You Can Accelerate Your Research at CRADL
Building infrastructure is often expensive, time-consuming, and may not be the right approach when conducting early discovery work. Renting at our AAALAC-accredited, full-service turnkey vivarium can help biotech, pharma, and academic organizations expand their research quickly and more efficiently.
CATALOG
Growing Selection of Immunodeficient Models
Our expanding portfolio including the NCG Plus Portfolio, a set of NCG mice that are highly immunodeficient. Each new model will provide specific benefits allowing for additional flexibility including altering human blood cell populations and making humanizing mice yourself easier than ever.
CATALOG
The SRG Rat – A Triple-Immunodeficient Rat Model
Lacking mature B, T, and NK cells? The SRG rat is ideal for tumor biology, oncology, immunology, xenograft, and transplant research.
DEMO TOOL
A Real-Time Solution to Procuring Animal Models
Secure the animals required for your research with our new, lightning-fast ordering experience, offering 24/7 visibility into availability, pricing, and immediate order confirmation.
CATALOG/TOOL
Custom Model Creation
Create a transgenic mouse or rat model tailored to your research needs with your dedicated project manager and option to personalize breeding plans, deliver cohorts of study-ready animals and access your colonies 24/7 through an online portal.
CATALOG
Ice-Free Cell Line and Research Biologics Sample Collection Kit
Submit your samples more easily than ever and keep study animals and research pathogen-free.
SOLUTIONS
Fill Staff Roles in Your Vivarium with Insourcing Solutions
If staff turnover or unexpected operational issues are slowing research at your vivarium, our Insourcing Solutions® staffing programs can help you secure experienced animal care technicians, veterinarians, vivarium managers, or other key roles to keep your research on track.
SOLUTIONS
Advance In Vivo Studies Quickly at a CRADL® Vivarium
CRADL®, Charles River’s Accelerator and Development Labs, provide rentable in vivo vivarium space with built-in animal care, IACUC protocol support, and expanded technical research services. You can start with a few study cages, scale cost-efficiently, and pivot quickly as you remain hands-on with your studies while we take care of the daily animal care and facility operations.
Learn more about our oncology services.