Sprague Dawley Rats (CD® IGS)

Crl:CD(SD)
Outbred

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Sprague Dawley Rat
Breeding Location

Sprague Dawley Rats (CD® IGS) Details

Known for their calm demeanor, adaptability, and genetic reliability, the Sprague Dawley (SD) rat has become indispensable for advancing our understanding of human health and disease. From pharmacology to cancer research, SD rats play a crucial role in helping scientists answer complex questions.

Our Sprague Dawley rat, the caesarean-derived (CD) IGS rat, originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. This rat was given to Charles River in 1950 by Sprague Dawley, Inc. In 1991, eight colonies were selected to form the IGS foundation colony. The Sprague Dawley rat was rederived into an isolator foundation colony in 1997. 

IGS refers to animals bred using the Charles River International Genetic Standardization Program, including the Crl:CD(SD) rat. The IGS program is a management system used to minimize inbreeding and manage random genetic drift that would otherwise lead to colony divergence among colonies bred in different locations worldwide. The IGS program is validated by direct genetic analysis of animals from the foundation colony and the barrier rooms.

Note: We also offer the CD® (SD) IGS SOPF Rat, which is bred in France.

Coat Color
White (albino)
Strain Code
001
Ideal For
General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, surgical model

CD IGS Rat US Growth Chart

LOCATION: Kingston
UNIT: K90
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LOCATION: Kingston
UNIT: K98
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LOCATION: Raleigh
UNIT: R06
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LOCATION: Raleigh
UNIT: R08
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LOCATION: Hollister
UNIT: H41
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Try out this model with our animal evaluation program (North America)

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Sprague Dawley Rats (CD® IGS) Details

Known for their calm demeanor, adaptability, and genetic reliability, the Sprague Dawley (SD) rat has become indispensable for advancing our understanding of human health and disease. From pharmacology to cancer research, SD rats play a crucial role in helping scientists answer complex questions.

Our Sprague Dawley rat, the caesarean-derived (CD) IGS rat, originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. This rat was given to Charles River in 1950 by Sprague Dawley, Inc. In 1991, eight colonies were selected to form the IGS foundation colony. The Sprague Dawley rat was rederived into an isolator foundation colony in 1997. 

IGS refers to animals bred using the Charles River International Genetic Standardization Program, including the Crl:CD(SD) rat. The IGS program is a management system used to minimize inbreeding and manage random genetic drift that would otherwise lead to colony divergence among colonies bred in different locations worldwide. The IGS program is validated by direct genetic analysis of animals from the foundation colony and the barrier rooms.

Note: We also offer the CD® (SD) IGS SOPF Rat, which is bred in France.

Coat Color
White (albino)
Strain Code
001
Ideal For
General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, surgical model

CD IGS Rat UK Growth Chart

Growth chart data should be used as a guideline only. 
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.

➤ DOWNLOAD OUR CATALOG for instant access to Standard List Pricing

➤ TALK TO US to discuss organization or volume-based discounts

Already have an eCommerce portal account?* Login to order research models, obtain quotes, view organization-specific pricing, and see inventory. Processing time required to validate new eCommerce access requests.

*eCommerce is available in US, Canada, UK, France, Germany, Austria, Netherlands, Denmark, Finland, Norway, Sweden, Spain, Portugal, Belgium, Luxembourg, and Switzerland 

Try out this model with our animal evaluation program (North America)

Try out this model with our animal evaluation program (Europe)

 

Sprague Dawley Rats (CD® IGS) Details

Known for their calm demeanor, adaptability, and genetic reliability, the Sprague Dawley (SD) rat has become indispensable for advancing our understanding of human health and disease. From pharmacology to cancer research, SD rats play a crucial role in helping scientists answer complex questions.

Our Sprague Dawley rat, the caesarean-derived (CD) IGS rat, originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. This rat was given to Charles River in 1950 by Sprague Dawley, Inc. In 1991, eight colonies were selected to form the IGS foundation colony. The Sprague Dawley rat was rederived into an isolator foundation colony in 1997. 

IGS refers to animals bred using the Charles River International Genetic Standardization Program, including the Crl:CD(SD) rat. The IGS program is a management system used to minimize inbreeding and manage random genetic drift that would otherwise lead to colony divergence among colonies bred in different locations worldwide. The IGS program is validated by direct genetic analysis of animals from the foundation colony and the barrier rooms.

Note: We also offer the CD® (SD) IGS SOPF Rat, which is bred in France.

Coat Color
White (albino)
Strain Code
001
Ideal For
General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, surgical model

CD IGS Rat Italy Growth Chart

Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.

➤ DOWNLOAD OUR CATALOG for instant access to Standard List Pricing

➤ TALK TO US to discuss organization or volume-based discounts

Already have an eCommerce portal account?* Login to order research models, obtain quotes, view organization-specific pricing, and see inventory. Processing time required to validate new eCommerce access requests.

*eCommerce is available in US, Canada, UK, France, Germany, Austria, Netherlands, Denmark, Finland, Norway, Sweden, Spain, Portugal, Belgium, Luxembourg, and Switzerland 

Try out this model with our animal evaluation program (North America)

Try out this model with our animal evaluation program (Europe)

 

Sprague Dawley Rats (CD® IGS) Details

Known for their calm demeanor, adaptability, and genetic reliability, the Sprague Dawley (SD) rat has become indispensable for advancing our understanding of human health and disease. From pharmacology to cancer research, SD rats play a crucial role in helping scientists answer complex questions.

Our Sprague Dawley rat, the caesarean-derived (CD) IGS rat, originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. This rat was given to Charles River in 1950 by Sprague Dawley, Inc. In 1991, eight colonies were selected to form the IGS foundation colony. The Sprague Dawley rat was rederived into an isolator foundation colony in 1997. 

IGS refers to animals bred using the Charles River International Genetic Standardization Program, including the Crl:CD(SD) rat. The IGS program is a management system used to minimize inbreeding and manage random genetic drift that would otherwise lead to colony divergence among colonies bred in different locations worldwide. The IGS program is validated by direct genetic analysis of animals from the foundation colony and the barrier rooms.

Note: We also offer the CD® (SD) IGS SOPF Rat, which is bred in France.

Coat Color
White (albino)
Strain Code
001
Ideal For
General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, surgical model

Growth Chart for CD® (SD) IGS Rat Colony at Vital River Laboratories in China

 

Please email us at [email protected] to request a health report for this model. For additional information on this animal model, please visit the CD® (SD) IGS rat page on the Vital River Laboratories website.

For additional information, including pricing details, please visit the CD® (SD) IGS rat page on the Vital River Laboratories website.

Try out this model with our animal evaluation program (North America)

Try out this model with our animal evaluation program (Europe)

 

Sprague Dawley Rats (CD® IGS) Details

Known for their calm demeanor, adaptability, and genetic reliability, the Sprague Dawley (SD) rat has become indispensable for advancing our understanding of human health and disease. From pharmacology to cancer research, SD rats play a crucial role in helping scientists answer complex questions.

Our Sprague Dawley rat, the caesarean-derived (CD) IGS rat, originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. This rat was given to Charles River in 1950 by Sprague Dawley, Inc. In 1991, eight colonies were selected to form the IGS foundation colony. The Sprague Dawley rat was rederived into an isolator foundation colony in 1997. 

IGS refers to animals bred using the Charles River International Genetic Standardization Program, including the Crl:CD(SD) rat. The IGS program is a management system used to minimize inbreeding and manage random genetic drift that would otherwise lead to colony divergence among colonies bred in different locations worldwide. The IGS program is validated by direct genetic analysis of animals from the foundation colony and the barrier rooms.

Note: We also offer the CD® (SD) IGS SOPF Rat, which is bred in France.

Coat Color
White (albino)
Strain Code
001
Ideal For
General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, surgical model

CD IGS Rat Germany Growth Chart

Growth chart data should be used as a guideline only. 
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.

➤ DOWNLOAD OUR CATALOG for instant access to Standard List Pricing

➤ TALK TO US to discuss organization or volume-based discounts

Already have an eCommerce portal account?* Login to order research models, obtain quotes, view organization-specific pricing, and see inventory. Processing time required to validate new eCommerce access requests.

*eCommerce is available in US, Canada, UK, France, Germany, Austria, Netherlands, Denmark, Finland, Norway, Sweden, Spain, Portugal, Belgium, Luxembourg, and Switzerland 

Try out this model with our animal evaluation program (North America)

Try out this model with our animal evaluation program (Europe)

 

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Resources for the CD® IGS (Sprague Dawley) Rat

Why are Sprague Dawley Rats Used in Research?

Sprague Dawley rats are valued for their versatility and are used in a wide range of scientific and biomedical research disciplines. Their physiological similarity to humans and predictable genetic traits make them ideal for:

Drug Development
  • Testing the safety, efficacy, and pharmacokinetics of new drugs before human trials (NCBI)
  • Understanding drug interactions and therapeutic mechanisms
Toxicology Studies
  • Assessing the toxicity of chemicals, pharmaceuticals, and environmental substances (National Toxicology Program)
  • Determining safe dosage levels for medications
Cancer Research
  • Studying tumor development, progression, and metastasis
  • Evaluating the effectiveness of experimental cancer treatments (American Association for Cancer Research)
Metabolic and Endocrine Disorders
  • Researching conditions like diabetes, obesity, and cardiovascular diseases (American Physiological Society)
  • Investigating hormonal regulation and metabolic pathways
Behavioral and Neurological Studies
  • Exploring disorders such as anxiety, depression, and Alzheimer's disease (Frontiers in Behavioral Neuroscience)
  • Understanding brain function, cognition, and behavior
Developmental Biology
  • Analyzing genetic factors influencing growth and development
  • Investigating the effects of prenatal exposures on fetal development (Journal of Developmental Biology)
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Frequently Asked Questions about Sprague Dawley Rats

  • What are the genetic characteristics of Sprague Dawley rats?

    Sprague Dawley rats are renowned for their genetic diversity and consistency, which are critical for producing reliable and reproducible experimental results. Key characteristics include:

    • Outbred Model: Unlike inbred strains, SD rats maintain a wider genetic variation, making findings more applicable to broader populations.
    • Uniform Traits: SD rats exhibit consistent growth rates, size, and reproductive capabilities, making them predictable and reliable test subjects.
    • High Adaptability: They thrive in diverse environments, ensuring consistent results across different research conditions.


    These genetic traits make SD rats an ideal choice for experiments requiring precise, repeatable outcomes.

  • Why are Sprague Dawley rats a preferred outbred rat model?

    Several factors make Sprague Dawley rats a favorite among researchers:

    • Calm Temperament: Their docile nature makes them easy to handle, reducing stress during experiments and improving accuracy.
    • Cost-Effectiveness: They breed efficiently, grow quickly, and are easy to maintain, keeping research costs manageable.
    • Reproducibility: With well-documented physiological baselines, researchers can depend on consistent data from study to study (National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs)).
    • Genetic Versatility: Their outbred status ensures a level of genetic diversity that enhances the applicability of research findings. These advantages have cemented Sprague Dawley rats as a go-to model for preclinical research across the globe.


    These advantages have cemented Sprague Dawley rats as a go-to model for preclinical research across the globe.

  • What are the therapeutic applications of Sprague Dawley rats?

    Sprague Dawley rats are integral to therapeutic research due to their physiological similarity to humans. Researchers leverage these traits to:

    • Test new therapies for chronic diseases like diabetes and cancer (American Diabetes Association)
    • Develop drugs targeting metabolic disorders and neurodegenerative conditions
    • Explore the effectiveness of experimental treatments in both acute and long-term studies


    Their ability to model human diseases accurately has been instrumental in the development of life-saving medications and innovative therapies.