Charles River’s antibody discovery experience provides you with dedicated antibody discovery and development expertise, guiding your vision toward the clinic with unprecedented support, speed, and customizability. Whether it’s an end-to-end antibody discovery need, or standalone antibody discovery services, we strive to be the only partner you need for your antibody discovery needs and beyond.
Endless Antibody Discovery Options, Simplified Workflows
Phage Display Antibody Discovery
- Highly diverse scFv or VHH phage display libraries
- Discover fully human, therapeutic-ready hits against any target of interest
- Receive royalty-free antibody lead panels in as few as eight weeks
Antibody Engineering and Optimization
- Simultaneous multi-parameter antibody engineering and optimization
- Antibody humanization, affinity maturation, and liability removal
- Reformatting for CAR-T, ADCs, nanobodies, bispecifics, and more
Characterization and Functionality
- Complete biochemical characterization of the receptor antibody interaction
- Robust evaluation of the mechanism of action and safety profile
- Primary cell functional assays including real-time monitoring of effector functions
Antibody Specificity and Off-Target Screening
- Optimization and screen against human proteins expressed in human cells
- Confirmation screen against hits for reproducibility and specificity
- Hit validation, relative affinities, and bioinformatic analysis with all results
Antibody In Vivo Efficacy and Safety
- PDX models for relevant disease modeling and antibody efficacy
- PK/PD studies ahead of preclinical assessments
- Tolerability and exploratory toxicology for early safety assessment
Custom Antibody Development
- Develop CHO clone pools of your 4-6 leads
- Assessment of formulation and manufacturability
- Material generation for late stage in vitro and in vivo Candidate selection studies and scale up to Toxicology and GMP Phase 1 Clinical supply
Zero to Antibody Hero: Laying the Groundwork for Preclinical Success
Curious about our antibody discovery services? Watch this on-demand webinar that showcases our end-to-end capabilities and robust data packages your antibody candidates will receive by partnering with us.
Watch the Webinar
What Makes our Antibody Discovery Services Different?
Innovative
Access platforms that support rapid and earlier safety evaluation and add insightful biophysical characterization data to your antibody discovery program to deliver the most therapeutically relevant candidates. Our teams’ robust experience and knowledge can help you overcome challenges and avoid missteps throughout the antibody discovery process.
Flexible
Providing a tailored experience for every client in antibody discovery, based on your unique vision, is central to our mission. Work with us on an end-to-end antibody discovery process or leverage only the services you need to properly develop and assess your antibody candidates, guiding you to the clinic with the greatest chance of success.
Collaborative
Understanding your unique vision for your antibody therapeutic allows us to provide a customized antibody discovery solution focused on IND-enabling studies. Our team provides a level of expertise that can take years to recruit and train in-house. We have seen over 400 antibody programs and can help you avoid common missteps and challenges in the discovery of antibody therapeutics.
Efficient
Leverage our rapid, proprietary technologies to save time in antibody discovery. We’ve optimized our processes based on the decades of experience on our team and designed them to discover the candidates best suited to succeed in preclinical and clinical evaluations, faster than ever before.
What Antibody Discovery Route is Right For Me?
Speak with one of our experts and let us help navigate the tailored solution works for you and your therapeutic goals.
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