PDX Cell Line Assays

In addition to more than 260 commercial human tumor PDX cell lines, we offer more than 75 proprietary cell lines derived from our PDX models, and this number continues to grow. Each cell line is fully characterized with selected clinical data and comprehensive molecular data for the originating tumor, and have been characterized by their sensitivity for up to 240 reference agents. Download our 2D Tumor Panel Screen Data.

 

Charles River offers in vitro patient-derived xenograft (PDX) screens using tumor cell lines in a 2D proliferation assay.
Figure 1: Schematic of 2D in vitro PDX assays. The patient-derived tumor material or PDX cell lines are cultured into a monolayer and tumor growth is monitored to test effects of compounds in pdx cell line assays.

By using tumor cell lines derived from our portfolio of PDX models, we retain characteristics such as expression and mutation profiles; this creates “matched pairs” of xenografts and corresponding cell lines. This allows you to improve translation by using the same models for your in vitro cell line assays, ex vivo and in vivo efficacy studies.


Webinar: Catching Patient Diversity In Vitro

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Discover how scientists are using in vitro PDX assays to optimize oncology research approaches and see how live-cell imaging and multiplex analysis can help us understand treatment efficacy.

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In Vitro Tumor Cell Line Screening

Improve speed and lower costs with fixed in vitro PDX model screening panels:

  • Solid tumor histotypes
  • Hematological cell lines
  • Asian cancer cell lines

Need a custom solution? We can create panels of up to 100 cell types for you. Our 2D in vitro PDX assays can be used in a variety of ways:

  • Assessment of potency and selectivity
  • Identification of mode of action via COMPARE analysis
  • Administration of combination studies
  • Analysis of multidrug resistance

 

Combining In Vitro and In Vivo PDX Models

Experience has shown us that integrating 2D in vitro PDX assays, ex vivo 3D, in vivo models and bioinformatics data creates a comprehensive picture of your therapy. Our team can guide your combined application of these tools to facilitate drug development and enhance the speed of your oncology research.

To learn more about our PDX model offerings, including molecular information, visit our Cancer Model Database.

 

Frequently Asked Questions (FAQs) in In Vitro PDX Assays Research

Have another question or need advice on which model is right for you?

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