Charles River offers a fully integrated service with a team of scientists, pathologists, veterinarians and surgeons in the field of musculoskeletal research. This integrated approach allows the comprehensive evaluation of bone and cartilage drug efficacy, musculoskeletal tissue healing and biocompatibility, orthopedic device efficacy and the effects of new orthobiologic applications.


  • Gonadectomy (ovariectomy and orchiectomy)-induced bone loss for osteoporosis drug testing
  • 5/6 nephrectomy model
  • TPTx (thyroparathyroidectomy) model
  • Schenk model in weanling rats (screen for anti-resorptive agents)
  • Bone defect models
  • Orthopedic models
  • Osteoarthritis models
  • Rheumatoid arthritis models

Note: Non-GLP efficacy models are also available for your early research.

Support Services

  • Imaging using bone densitometry techniques
  • Biochemical markers of bone and cartilage turnover
  • Radiographic diagnostics (X-ray)
  • Histomorphometry and histology
  • Biomechanical strength testing
  • Micro-CT scanning